ABSTRACT
This study prospectively examined the intranasal distribution of nasal spray after nasal septal correction and decongestant administration. A cohort of 20 patients was assessed for the distribution of nasal spray before and after nasal septum surgery. Sprays were dyed and administered one puff per nostril when patients hold their head up in an upright position. Before and after decongestant administration, the intranasal distribution was semi-quantitatively determined by nasal endoscopy. The results showed that the dyed drug was preferentially sprayed onto the nasal vestibule, the head of the inferior turbinate, the anterior part of septum and nasal floor. As far as the anterior-inferior segment of the nasal cavity was concerned, the distribution was found to be influenced neither by the decongestant nor by the surgery (P>0.05). However, both the decongestant and surgery expanded the distribution to the anatomical structures in the superior and posterior nasal cavity such as olfactory fissure, middle turbinate head and middle nasal meatus. No distribution was observed in the sphenoethmoidal recess, posterior septum, tail of inferior turbinate and nasopharynx. It was concluded that nasal septum surgery and decongestant administration significantly improves nasal spray distribution in the nasal cavity.
ABSTRACT
OBJECTIVES@#To investigate the effet of nasal septum operation combined with nasal sinuses on postoperative nasal septum.@*METHOD@#Sixty-five patients with deflection of nasal septum complicating chronic sinusitis were underwent nasal septum and nasal sinus operations under nasal endoscope. Postoperative nasal septum recover were observed and compared with patients underwent only simple nasal septum operation.@*RESULT@#Patients underwent nasal septum operations combined with nasal sinus, postoperative symptoms were more serious at early than simple nasal septum operations. At 3 months after operation, satisfactory degree of the former group were higher than the latter, and the former group didn't have complications such as nasal septum infection.@*CONCLUSION@#Nasal septum operations combined with nasal sinus have no harmful effect on the prognosis of nasal septum, so it was safe and reliable.
Subject(s)
Adolescent , Adult , Female , Humans , Male , Middle Aged , Young Adult , Chronic Disease , Endoscopy , Nasal Septum , General Surgery , Paranasal Sinuses , General Surgery , Prognosis , Sinusitis , General Surgery , Treatment OutcomeABSTRACT
It is discovered in massive clinical practices that Chinese medicine intervention in the acute stage of stroke can make enormous improvement in stroke prognosis,moreover in many cases,which is prompted to be related with the improvement of hydrocephalus in the acute stage of stroke.This article makes a preliminary theoretical discussion that the function of Chinese medicine to hydrocephalus is possibly related with the following three hypotheses:removing the blood heat and dredging the ori ces can promote diuresis;catharsis and clearing turbidity can remove water;clearing the liver and suppressing wind can facilitate water.And elaborate the possible mechanisms in details:removing the blood heat and dredging the ori ces can remove the blood stasis and promote diuresis;catharise and clearing turbidity can smooth Fu-qi and make qi and blood spread,and achieve the goal of dredging the ori ces to free the collaterals and alleviate hydrocephalus;clearing the liver and suppressing wind may have many kinds of e ects such as suppressing re,smoothing qi,harmonizing blood,removing the blood stasis and stoppingconvulsion,and then smooth qi and blood to control or alleviate hydrocephalus.
ABSTRACT
<p><b>OBJECTIVE</b>To study the influence of intranasal medication on the structure, pathology and reversibility of the nasal mucosa to provide a basis for the feasibility of intranasal route of drug administration.</p><p><b>METHODS</b>Nasal drops of gentamicin were placed in the nasal cavity of rabbits for 3, 5, 7, 14 and 28 days. After that, the drops were stopped and drugs protecting the nasomucosa were used for one and three weeks. After being sacrificed over time, the nasomucosa of the rabbit was observed under optical and electron microscopes.</p><p><b>RESULTS</b>Damage to the nasal mucosa appeared to different extents with prolonged use of nasal drops. Within 3 - 7 days of applying the drug, damages to the nasal mucosa gradually appeared, and after two and four weeks, were most serious. After stopping the drug, the nasal mucosa was gradually restored.</p><p><b>CONCLUSION</b>Damages of drugs to the nasal mucosa could be restored. The intranasal route of drug administration would be feasible and clinically applicable.</p>